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Post Doctoral Research Visit F/M Bifurcation and robustness analysis in structured population models: Application to female reproductive cycles



Job description

Contexte et atouts du poste

The postdoc position is open in the framework of the ANR project OVOPAUSE led by MUSCA, gathering researchers from different institutions and scientific background (applied mathematics, developmental and reproductive biology).

The position is an opportunity to be involved in a strongly interdisciplinary consortium, and to strengthen experience in mathematical and computational biology by working on the analysis of coupled ODE-PDE models.


Mission confiée

The detailed subject is avalaible at: From these studies, theoretical results on the longtime analysis of coupled PDE/ODE systems are expected, as well as outcomes in comparative physiology highlighting the shared mechanisms and species-specific differences in germ cell dynamics among vertebrate species (e.g. in mammals compared to fish).


References


[1] G.

Ballif, F.

Clément, and R.

Yvinec.

Averaging of a stochastic slow-fast model for population dynamics: application to the development of ovarian follicles.

SIAM J.

Appl.

Math., 82:359–380, 2022.
[2] G.

Ballif, F.

Clément, and R.

Yvinec.

Nonlinear compartmental modeling to monitor ovarian follicle popu- lation dynamics on the whole lifespan.

J.

Math.

Biol., 89:9, 2024.
[3] F.

Clément, L.

Fostier, and R.

Yvinec.

Bifurcation analysis of a size-structured population model: application to oocyte dynamics and ovarian cycle.

SIAM J.

Appl.

Dyn.

Syst.

(in press), 2025.
[4] F.

Clément and D.

Monniaux.

Mathematical modeling of ovarian follicle development: A population dynamics viewpoint.

Curr.

Opin.

Endocr.

Metab.

Res., 18:54–61, 2021.
[5] R.

Yvinec, P.

Crépieux, E.

Reiter, A.

Poupon, and F.

Clément.

Advances in computational modeling approaches of pituitary gonadotropin signaling.

Expert Opin.

Drug Discov., 13:799–813, 2018


Principales activités

  • Extend and couple existing models

  • Perform extensive bifurcation analysis on the coupled model

  • Develop and implement numerical schemes suited for the coupled model

  • Characterize the properties of the oscillatory solutions

  • Perform a sensitivity/robustness analysis applied to the oscillatory solutions

  • Position the results with respect to the mathematical and biological literature in the field

  • Write and disseminate the results to the scientific community
  • Compétences

    Ph.D in applied Mathematics, with expert knowledge in analysis and numerical simulation of ODEs and PDEs. Experience with either sensitivity/identifiability analysis or parameter estimation will be greatly appreciated.
    Strong motivation for biological applications and work in an interdisciplinary context.

    Avantages

  • Subsidized meals

  • Partial reimbursement of public transport costs

  • Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working hours) + possibility of exceptional leave (sick children, moving home, etc.)

  • Possibility of teleworking (after 6 months of employment) and flexible organization of working hours

  • Professional equipment available (videoconferencing, loan of computer equipment, etc.)

  • Social, cultural and sports events and activities

  • Access to vocational training

  • Social security coverage
  • Rémunération

    Monthly gross salary : 2.788 euros


    Required Skill Profession

    Life Scientists



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